Detailed Notes on modafinil dosage
Detailed Notes on modafinil dosage
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Warfarin's less strong R-enantiomer is metabolized partially by CYP3A4 (in addition to CYP1A2 and CYP2C19). Check INR a lot more regularly if coadministered with inhibitors of these isoenzymes and adjust warfarin dose if needed.
You may have troubles walking Ordinarily For anyone who is unsteady since you feel dizzy. These symptoms can improve when your dose of FYCOMPA is amplified. Your chance of feeling dizzy and getting complications walking Typically can be increased In case you are elderly; Sleepiness and tiredness; Enhanced risk of falls. Using FYCOMPA can raise your potential for falling. These falls might cause critical accidents. Your danger of falling may very well be higher Should you be aged; A serious allergic reaction that will impact the skin or other parts of Your system which include your liver, kidneys, coronary heart, or blood cells.
itraconazole will enhance the degree or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Don't cease using your CPAP device during sleep Unless of course your physician lets you know to. The mix of cure with CPAP and Provigil may be needed to most effective take care of your problem.
Use: To further improve wakefulness in patients with abnormal sleepiness associated with shift do the job problem.
Applying this medication with any of the following medicines is not advised. Your doctor may perhaps make a decision not to take care of you with more info this medication or improve several of the other medicines you are taking.
Prevent or substitute A different drug for these drugs when doable. Consider for loss of therapeutic influence if medication should be coadministered. Change dose In accordance with prescribing information if needed.
Keep away from or substitute Yet another drug for these medicines when feasible. Assess for loss of therapeutic impact if medication need to be coadministered. Adjust dose according to prescribing information and facts if needed.
stiripentol will increase the degree or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Intently. Take into account reducing the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.
In Japan, modafinil is Plan I psychotropic drug. Consequently it is taken into account to have a high possible for abuse and dependence, and it is for that reason subject matter to demanding regulations.
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No distinct antidote exists for that harmful effects of a PROVIGIL overdose. This sort of overdoses really should be managed with generally supportive care, such as cardiovascular monitoring.
Modafinil influences the central nervous program. This medication may perhaps impair your pondering or reactions. Be mindful in the event you generate or do just about anything that requires you to definitely be warn. Steer clear of other unsafe activities until finally you know the way this medication will impact your amount of wakefulness.
When modafinil is usually uncovered to be Safe and sound and considerable adverse consequences are unusual, including in pediatric narcolepsy scenarios (sleep Conditions in kids), You can find evidence that extensive-phrase use can lead to tolerance in a few individuals.